Mediterr J Rheumatol 2023;34(4):531-6
Soft Tissue Sarcomas Mimicking Benign Inflammatory Processes: A Diagnostic Dilemma
Authors Information

1Department of Diagnostic and Interventional Radiology, University Hospitals of North

Midlands NHS Trust, Stoke on Trent, United Kingdom

2Department of Diagnostic and Interventional Radiology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt

3Department of Musculoskeletal Pathology, The Royal Orthopaedic Hospital NHS Foundation Trust, Robert Aitken Institute for Clinical Research (Level 3), University of Birmingham, Birmingham, United Kingdom

C Furtado


Background: Soft tissue sarcomas are rare and often go undetected until a later stage, particularly when they present as intra-articular or tenosynovial lesions mimicking benign synovial pathologies. The failure to distinguish between malignant and benign synovial disease can have a significant impact on patient outcomes and limit alternatives for local control surgery and limb salvage. Case Description: In this case series, we present two cases of soft tissue sarcomas, one being an intra-articular synovial chondrosarcoma, and the other a pleomorphic spindle cell sarcoma centred along tendon sheaths. Radiologically, the initial clinical presentation of these cases resembled benign synovial pathologies, leading to a delay in diagnosis and treatment. Conclusion: Our study underscores the importance of maintaining a low threshold of suspicion for surveillance, a multidisciplinary approach, and early histological diagnosis to ensure appropriate timely treatment and a favourable prognosis for patients with soft tissue sarcomas.

Cite this article as: Furtado C, Zeitoun R, Wilkes J, Sumathi V, Tony G. Soft Tissue Sarcomas Mimicking Benign Inflammatory Processes: A Diagnostic Dilemma. Mediterr J Rheumatol 2023;34(4):531-6.

Article Submitted: 27 Apr 2023; Revised Form: 17 Jun 2023; Article Accepted: 13 Jul 2023; Available Online: 27 Aug 2023

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©2023 The Author(s).