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Mediterr J Rheumatol 2019;30(1):16-25
Complex Regional Pain Syndrome: An update
Authors Information

First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece

References
  1. Bussa M, Mascaro A, Cuffaro L, Rinaldi S. Adult complex regional pain syndrome type I: A narrative review. PM R 2017;9:707-19. [https://doi.org/10.1016/j.pmrj.2016.11.006] [PMID: 27890578]
  2. Merskey H, Addison RG, Beric A, Blumberg H,  Bogduk N,  Boivie J, et al. Detailed descriptions of pain syndromes. In: Merskey H, Bogduk N, editors. Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms, 2nd edn. Seattle: IASP Press: 1994. P. 40-43.
  3. Harden R, Bruehl S. Diagnostic criteria: The statistical derivation of the four criterion factors. In: Wilson PR, Stanton-Hicks M, Harden RN, editors. CRPS: Current Diagnosis and Therapy. Seattle: IASP Press: 2005. P. 45–58.
  4. Harden R, Bruehl S. Diagnosis of complex regional pain syndrome: signs, symptoms, and new empirically derived diagnostic criteria. Clin J Pain 2006;22:415-9. [https://doi.org/10.1097/01.ajp.0000194279.36261.3e] [PMID: 16772794]
  5. Bruehl S, Harden R, Galer B, Saltza S, Bertram M, Backonja M, et al. External validation of IASP diagnostic criteria for complex regional pain syndrome and proposed research diagnostic criteria. Pain 1999;81:147–54. [PMID: 10353502]
  6. Galer B, Bruehl S, Harden R. IASP Diagnostic criteria for complex regional pain syndrome: A preliminary empirical validation study. Clin J Pain 1998;14:48-54. [PMID: 9535313]
  7. Harden R, Bruehl S, Stanton-Hicks M, Wilson P. Proposed new diagnostic criteria for complex regional pain syndrome. Pain Med 2007;8:326-31. [https://doi.org/10.1111/j.1526-4637.2006.00169.x] [PMID: 17610454]
  8. Sandroni P, Benrud-Larson L, McClelland R, Low P. Complex regional pain syndrome type I: incidence and prevalence in Olmsted county, a population-based study. Pain 2003;103:199-207. [PMID: 12749974]
  9. De Mos M, de Bruijn AG, Huygen FJ, Dieleman JP, Stricker BH, Sturkenboom MC. The incidence of complex regional pain syndrome: a population-based study. Pain 2007;129:12-20. [https://doi.org/10.1016/j.pain.2006.09.008] [PMID: 17084977 ]
  10. Elsharydah A, Loo N, Minhajuddin A, Kandil E. Complex regional pain syndrome type 1 predictors- Epidemiological perspective from a national database analysis. J Clin Anesth 2017;39:34-7. [https://doi.org/10.1016/j.jclinane.2017.03.027] [PMID: 28494904]
  11. Reinders M, Geertzen J, Dijkstra P. Complex regional pain syndrome type I: Use of the International Association for the Study of Pain diagnostic criteria defined in 1994. Clin J Pain 2002;18:207-15. [PMID: 12131062]
  12. Bean D, Johnson M, Heiss-Dunlop W, Lee A, Kydd R. Do psychological factors influence recovery from complex regional pain syndrome type 1? A prospective study. Pain 2015;156:2310-8. [https://doi.org/10.1097/j.pain.0000000000000282] [PMID: 26133727]
  13. Goh E, Chidambaram S, Ma D. Complex regional pain syndrome: A recent update. Burns Trauma 2017;5:2. [https://doi.org/10.1186/s41038-016-0066-4] [PMID: 28127572] [PMCID: PMC5244710]
  14. Veldman P, Reynen H, Arntz I, Goris R. Signs and symptoms of reflex sympathetic dystrophy: Prospective study of 829 patients. Lancet 1993;342:1012-6. [PMID: 8105263]
  15. GalveVilla M, Rittig-Rasmussen B, Moeller Schear Mikkelsen L, Groendahl Poulsen A. Complex regional pain syndrome. Man Ther 2016;26:223-30. [https://doi.org/10.1016/j.math.2016.07.001] [PMID: 27491326]
  16. Birklein F. Complex regional pain syndrome. J Neurol 2005;252:131-8. [https://doi.org/10.1007/s00415-005-0737-8] [PMID: 15729516]
  17. Wasner G, Schattschneider J, Binder A, Baron R. Complex regional pain syndrome - diagnosis, mechanisms, CNS involvement and therapy. Spinal Cord 2003;41:61-75. [https://doi.org/10.1038/sj.sc.3101404] [PMID: 12595868]
  18. Cappello ZJ, Kasdan ML, Louis DS. Meta-analysis of imaging techniques for the diagnosis of complex regional pain syndrome type I. J Hand Surg Am 2012;37:288-96. [https://doi.org/10.1016/j.jhsa.2011.10.035] [PMID: 22177715]
  19. Wuppenhorst N, Maier C, Frettloh J, Pennekamp W, Nicolas V. Sensitivity and specificity of 3-phase bone scintigraphy in the diagnosis of complex regional pain syndrome of the upper extremity. Clin J Pain 2010;26:182-9. [https://doi.org/10.1097/AJP.0b013e3181c20207] [PMID: 20173431]
  20. Wertli M, Brunner F, Steurer J, Held U. Usefulness of bone scintigraphy for the diagnosis of complex regional pain syndrome 1: A systematic review and Bayesian meta-analysis. PLoS One 2017;12(3):e0173688. [https://doi.org/10.1371/journal.pone.0173688] [PMID: 28301606] [PMCID: PMC5354289]
  21. Krämer HH, Hofbauer LC, Szalay G, Breimhorst M, Eberle T, Zieschang K, et al. Osteoprotegerin: A new biomarker for impaired bone metabolism in complex regional pain syndrome? Pain 2014;155:889-95. [https://doi.org/10.1016/j.pain.2014.01.014] [PMID: 24447513]
  22. Maihöfner C, Forster C, Birklein F, Neundörfer B, Handwerker H. Brain processing during mechanical hyperalgesia in complex regional pain syndrome: A functional MRI study. Pain 2005;114:93-103. [https://doi.org/10.1016/j.pain.2004.12.001] [PMID: 15733635]
  23. Hotta J, Saari J, Koskinen M, Hlushchuk Y, Forss N, Hari R. Abnormal brain responses to action observation in complex regional pain syndrome. J Pain 2017;18:255-65. [https://doi.org/10.1016/j.jpain.2016.10.017] [PMID: 27847313]
  24. Kortekaas M, Niehof S, Stolker R, Huygen F. Pathophysiological mechanisms involved in vasomotor disturbances in complex regional pain syndrome and implications for therapy: A review. Pain Pract 2016;16:905-14. [https://doi.org/10.1111/papr.12403] [PMID: 26547635]
  25. Parkitny L, McAuley J, Di Pietro F, Stanton T, O'Connell N, Marinus J, et al. Inflammation in complex regional pain syndrome: A systematic review and meta-analysis. Neurology 2013;80:106-17. [https://doi.org/10.1212/WNL.0b013e31827b1aa1] [PMID: 23267031] [PMCID: PMC3589200]
  26. Dirckx M, Stronks D, van Bodegraven-Hof E, Wesseldijk F, Groeneweg JG, Huygen FJ. Inflammation in cold complex regional pain syndrome. Acta Anaesthesiol Scand 2015;59:733-9. [https://doi.org/10.1111/aas.12465] [PMID: 25598133]
  27. Littlejohn G. Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome. Nat Rev Rheumatol 2015;11:639-48. [https://doi.org/10.1038/nrrheum.2015.100] [PMID: 26241184]
  28. Li W, Guo T, Liang D, Suan Y, Kingery W, Clark J. Substance P signaling controls mast cell activation, degranulation, and nociceptive sensitization in a rat fracture model of complex regional pain syndrome. Anesthesiology 2012;116:882-95. [https://doi.org/10.1097/ALN.0b013e31824bb303] [PMID: 22343473] [PMCID: PMC3311711]
  29. Urits I, Shen A, Jones M, Viswanath O, Kaye A. Complex regional pain syndrome, current concepts and treatment options. Curr Pain Headache Rep 2018;22:10. [https://doi.org/10.1007/s11916-018-0667-7] [PMID: 29404787]
  30. Terkelsen A, Mølgaard H, Hansen J, Finnerup N, Krøner K, Jensen T. Heart rate variability in complex regional pain syndrome during rest and mental and orthostatic stress. Anesthesiology 2012;116:133-46. [https://doi.org/10.1097/ALN.0b013e31823bbfb0] [PMID: 22089824]
  31. Kurvers H, Jacobs M, Beuk R, van den Wildenberg F, Kitslaar P, Slaaf D, et al. Reflex sympathetic dystrophy: evolution of microcirculatory disturbances in time. Pain 1995;60:333-40. [PMID: 7596630]
  32. Baron R, Schattschneider J, Binder A, Siebrecht D, Wasner G. Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: A case–control study. Lancet 2002;359:1655-60. [https://doi.org/10.1016/S0140-6736(02)08589-6] [PMID: 12020526]
  33. Bruehl S. An update on the pathophysiology of complex regional pain syndrome. Anesthesiology 2010;113:713-25. [https://doi.org/10.1097/ALN.0b013e3181e3db38] [PMID: 20693883]
  34. Birklein F, Riedl B, Sieweke N, Weber M, Neundörfer B. Neurological findings in complex regional pain syndromes-analysis of 145 cases. Acta Neurol Scand 2000;101:262-9. [PMID: 10770524]
  35. Maihofner C, Baron R, DeCol R, Binder A, Birklein F, Deuschl G, et al. The motor system shows adaptive changes in complex regional pain syndrome. Brain 2007;130:2671- 87. [https://doi.org/10.1093/brain/awm131] [PMID: 17575278]
  36. Di Pietro F, McAuley J, Parkitny L, Lotze M, Wand B, Moseley G, et al. Primary motor cortex function in complex regional pain syndrome: A systematic review and meta-analysis. J Pain 2013;14:1270-88. [https://doi.org/10.1016/j.jpain.2013.07.004] [PMID: 24035350]
  37. Di Pietro F, McAuley J, Parkitny L, Lotze M, Wand BM, Moseley G, et al. Primary somatosensory cortex function in complex regional pain syndrome: A systematic review and meta-analysis. J Pain 2013;14:1001-18. [https://doi.org/10.1016/j.jpain.2013.04.001] [PMID: 23726046]
  38. Maihöfner C, Forster C, Birklein F, Neundörfer B, Handwerker H. Brain processing during mechanical hyperalgesia in complex regional pain syndrome: A functional MRI study. Pain 2005;114:93-103. [https://doi.org/10.1016/j.pain.2004.12.001] [PMID: 15733635]
  39. Schwenkreis P, Maier C, Tegenthoff M. Functional imaging of central nervous system involvement in complex regional pain syndrome. AJNR Am J Neuroradiol 2009;30:1279-84. [https://doi.org/10.3174/ajnr.A1630] [PMID: 19386737]
  40. Bean D, Johnson M, Kydd R. Relationships between psychological factors, pain, and disability in complex regional pain syndrome and low back pain. Clin J Pain 2014;30:647-53. [https://doi.org/10.1097/AJP.0000000000000007] [PMID: 24135903]
  41. Beerthuizen A, Stronks D, Huygen F, Passchier J, Klein J, Spijker A. The association between psychological factors and the development of complex regional pain syndrome type 1 (CRPS1) – A prospective multicenter study. Eur J Pain 2011;15:971-5. [https://doi.org/10.1016/j.ejpain.2011.02.008] [PMID: 21459637]
  42. Beerthuizen A, van 't Spijker A, Huygen FJ, Klein J, de Wit R. Is there an association between psychological factors and the complex regional pain syndrome type 1 (CRPS1) in adults? A systematic review. Pain 2009;145:52-9. [https://doi.org/10.1016/j.pain.2009.05.003] [PMID: 19573987]
  43. Kohr D, Singh P, Tschernatsch M, Kaps M, Pouokam E, Diener M, et al. Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome. Pain 2011;152:2690-700. [https://doi.org/10.1016/j.pain.2011.06.012] [PMID: 21816540]
  44. Dubuis E, Thompson V, Leite M, Blaes F, Maihöfner C, Greensmith D, et al. Longstanding complex regional pain syndrome is associated with activating autoantibodies against alpha-1a adrenoceptors. Pain 2014;155:2408-17. [https://doi.org/10.1016/j.pain.2014.09.022] [PMID: 25250722]
  45. Kohr D, Tschernatsch M, Schmitz K, Singh P, Kaps M, Schäfer K, et al. Autoantibodies in complex regional pain syndrome bind to a differentiation-dependent neuronal surface autoantigen. Pain 2009;143:246-51. [https://doi.org/10.1016/j.pain.2009.03.009] [PMID: 19375222]
  46. Goebel A, Baranowski A, Maurer K, Ghiai A, McCabe C, Ambler G. Intravenous immunoglobulin treatment of the complex regional pain syndrome. Ann Intern Med 2010;152:152-8. [https://doi.org/10.7326/0003-4819-152-3-201002020-00006] [PMID: 20124231]
  47. Goebel A, Bisla J, Carganillo R, Frank B, Gupta R, Kelly J, et al. Low-dose intravenous immunoglobulin treatment for long-standing complex regional pain syndrome: A randomized trial. Ann Intern Med 2017;167:476-83. [https://doi.org/10.7326/M17-0509] [PMID: 28973211]
  48. Grieve S, Adams J, McCabe C. 'What I really needed was the truth'. Exploring the information needs of people with complex regional pain syndrome. Musculoskeletal Care 2016;14:15-25. [https://doi.org/10.1002/msc.1107] [PMID: 26076593]
  49. Breuer A, Mainka T, Hansel N, Maier C, Krumova E. Short-term treatment with parecoxib for complex regional pain syndrome: A randomized, placebo- controlled double-blind trial. Pain Physician 2014;17:127-37. [PMID: 24658473]
  50. Kalita J, Vajpayee A, Misra UK. Comparison of prednisolone with piroxicam in complex regional pain syndrome following stroke: a randomized controlled trial. QJM 2006;99:89-95. [https://doi.org/10.1093/qjmed/hcl004] [PMID: 16428335]
  51. Christensen K, Jensen E, Noer I. The reflex dystrophy syndrome response to treatment with systemic corticosteroids. ActaChir Scand 1982;148:653-5. [PMID: 6763435]
  52. Braus DF, Krauss J, Strobel J. The shoulder-hand syndrome after stroke: a prospective clinical trial. Ann Neurol 1994;36:728-33. [https://doi.org/10.1002/ana.410360507] [PMID: 7526774]
  53. Grundberg A. Reflex sympathetic dystrophy: Treatment with long-acting intramuscular corticosteroids. J Hand Surg Am. 1996;21:667-70. [https://doi.org/10.1016/S0363-5023(96)80023-2] [PMID: 8842963]
  54. Bianchi C, Rossi S, Turi S, Brambilla A, Felisari G, Mascheri D. Long-term functional outcome measures in corticosteroid-treated complex regional pain syndrome. Eura Medicophys 2006;42:103-11. [PMID: 16767061]
  55. Barbalinardo S, Loer S, Goebel A, Perez R. The treatment of longstanding complex regional pain syndrome with oral steroids. Pain Med 2016;17:337-43. [https://doi.org/10.1093/pm/pnv002] [PMID: 26814238]
  56. Adami S, Fossaluzza V, Gatti D, Fracassi E, Braga V. Bisphosphonate therapy of reflex sympathetic dystrophy syndrome. Ann Rheum Dis 1997;56:201-4. [PMID: 9135227] [PMCID: PMC1752343]
  57. Manicourt D, Brasseur J, Boutsen Y, Depreseux G, Devogelaer J. Role of alendronate in therapy for posttraumatic complex regional pain syndrome type I of the lower extremity. Arthritis Rheum 2004;50:3690-7. [https://doi.org/10.1002/art.20591] [PMID: 15529370]
  58. Varenna M, Zucchi F, Ghiringhelli D, Binelli L, Bevilacqua M, Bettica P, et al. Intravenous clodronate in the treatment of reflex sympathetic dystrophy syndrome. A randomized, double blind, placebo controlled study. J Rheumatol 2000;27:1477-83. [PMID: 10852274]
  59. Varenna M, Adami S, Rossini M, Gatti D, Idolazzi L, Zucchi F, et al. Treatment of complex regional pain syndrome type I with neridronate: A randomized, double-blind, placebo-controlled study. Rheumatology 2013;52:534-42. [https://doi.org/10.1093/rheumatology/kes312] [PMID: 23204550]
  60. Robinson J, Sandom J, Chapman P. Efficacy of pamidronate in complex regional pain syndrome type I. Pain Med 2004;5:276-80. [https://doi.org/10.1111/j.1526-4637.2004.04038.x] [PMID: 15367305]
  61. Eun Young H, Hyeyun K, Sang Hee I. Pamidronate effect compared with a steroid on complex regional pain syndrome type I: Pilot randomised trial. Neth J Med 2016;74:30-5. [PMID: 26819359]
  62. Żyluk A, Puchalski P. Effectiveness of complex regional pain syndrome treatment: A systematic review. Neurol Neurochir Pol 2018;52:326-33. [https://doi.org/10.1016/j.pjnns.2018.03.001] [PMID: 29559178]
  63. Gobelet C, Meier J, Schaffner W, Bischof-Delaloye A, Gerster JC, Burckhardt P. Calcitonin and reflex sympathetic dystrophy syndrome. Clin Rheumatol 1986;5:382-8.
  64. Gobelet C, Waldburger M, Meier J. The effect of adding calcitonin to physical treatment on reflex sympathetic dystrophy. Pain 1992;48:171-5. [PMID: 1589234]
  65. Bickerstaff D, Kanis J. The use of nasal calcitonin in the treatment of post-traumatic algodystrophy. Br J Rheumatol 1991;30:291-4. [PMID: 1863827] [http://doi.org/10.1093/rheumatology/30.4.291]
  66. Sahin F, Yilmaz F, Kotevoglu N, Kuran B. Efficacy of salmon calcitonin in complex regional pain syndrome (type 1) in addition to physical therapy. Clin Rheumatol 2006;25:143-8. [https://doi.org/10.1007/s10067-005-1153-2] [PMID: 15980934]
  67. Wells G, Chernoff J, Gilligan J, Krause D. Does salmon calcitonin cause cancer? A review and meta-analysis. Osteoporos Int 2016;27:13-9. [https://doi.org/10.1007/s00198-015-3339-z] [PMID: 26438308] [PMCID: PMC4715844]
  68. Zuurmond W, Langendijk P, Bezemer P, Brink H, de Lange J, van loenen A. Treatment of acute reflex sympathetic dystrophy with DMSO 50% in a fatty cream. Acta Anaesthesiol Scand 1996;40:364-7. [PMID: 8721469]
  69. Perez R, Zuurmond W, Bezemer P, Kuik D, van Loenen A, de Lange J, et al. The treatment of complex regional pain syndrome type I with free radical scavengers: A randomized controlled study. Pain 2003;102:297-307. [PMID: 12670672]
  70. Geertzen J, de Bruijn H, de Bruijn-Kofman A, Arendzen J. Reflex sympathetic dystrophy: Early treatment and psychological aspects. Arch Phys Med Rehabil 1994;75:442-6. [PMID: 8172505]
  71. Perez R, Pragt E, Geurts J, Zuurmond W, Patijn J, van Kleef M. Treatment of patients with complex regional pain syndrome type I with mannitol: A prospective, randomized, placebo-controlled, double-blinded study. J Pain 2008;9:678-86. [https://doi.org/10.1016/j.jpain.2008.02.005] [PMID: 18403271]
  72. Aïma F, Klouchea S, Frisona A, Bauera T, Hardya P. Efficacy of vitamin C in preventing complex regional pain syndrome after wrist fracture: A systematic review and meta-analysis. Orthop Traumatol Surg Res 2017;103:465-70. [https://doi.org/10.1016/j.otsr.2016.12.021] [PMID: 28274883]
  73. Van de Vusse A, Stomp-van den Berg S, Kessels A, Weber W. Randomised controlled trial of gabapentin in complex regional pain syndrome type 1. BMC Neurol 2004;4:13. [https://doi.org/10.1186/1471-2377-4-13] [PMID: 15453912] [PMCID: PMC523854]
  74. Ghostine S, Comair Y, Turner D, Kassell N, Azar C. Phenoxybenzamine in the treatment of causalgia. Report of 40 cases. J Neurosurg 1984;60:1263-8.
  75. Malik V, Inchiosa M Jr, Mustafa K, Sanapati M, Pimentel M Jr, Frost E. Intravenous regional phenoxybenzamine in the treatment of reflex sympathetic dystrophy. Anesthesiology 1998;88:823-7.
  76. Davis K, Treede R, Raja S, Meyer R, Campbell J. Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain. Pain 1991;47:309-17. [PMID: 1664508]
  77. Muizelaar J, Kleyer M, Hertogs I, DeLange D. Complex regional pain syndrome (reflex sympathetic dystrophy and causalgia): management with the calcium channel blocker nifedipine and/or the alpha-sympathetic blocker phenoxybenzamine in 59 patients. Clin Neurol Neurosurg 1997;99:26-30. [PMID: 9107464]
  78. Wertli M, Kessels A, Perez R, Bachmann L, Brunner F. Rational pain management in complex regional pain syndrome 1 (CRPS 1)—A network meta-analysis. Pain Med 2014;15:1575-89. [https://doi.org/10.1111/pme.12466] [PMID: 25234478]
  79. Perez R, Zollinger P, Dijkstra P, Thomassen-Hilgersom I, Zuurmond W, Rosenbrand K, et al. Evidence based guidelines for complex regional pain syndrome type 1. BMC Neurol 2010;10:20. [https://doi.org/10.1186/1471-2377-10-20] [PMID: 20356382] [PMCID: PMC2861029]
  80. Oerlemans H, Oostendorp R, de Boo T, Goris R. Pain and reduced mobility in complex regional pain syndrome I: Outcome of a prospective randomised controlled clinical trial of adjuvant physical therapy versus occupational therapy. Pain 1999;83:77-83. [PMID: 10506674]
  81. Daly A, Bialocerkowski A. Does evidence support physiotherapy management of adult complex regional pain syndrome type one? A systematic review. Eur J Pain 2009;13:339-53. [https://doi.org/10.1016/j.ejpain.2008.05.003] [PMID: 18619873]
  82. Gaspar A, Castro A, Antunes F. Mirror box therapy in the complex regional pain syndrome type I. Acta Fisiatr 2010;17:126-9.