Mediterr J Rheumatol 2018;29(2):89-91
Orf disease in a patient with rheumatoid arthritis
Authors Information

1: Rheumatology Department, General Hospital of Thessaloniki “Agios Pavlos”, Thessaloniki, Greece
2: Consultant General Practitioner, Thessaloniki, Greece
3: Consultant Dermatologist, Thessaloniki, Greece


Orf disease is a viral infection, affecting patients being involved in the care of livestock either professionally or habitually. It is also known as ecthyma contagious, contagious pustular dermatitis or infectious euphoria being a rare zoonotic disease caused by an epitheliotropic DNA virus from the parapoxvirus group.  We report a case of Orf disease affecting the hand of a patient with rheumatoid arthritis (RA) on treatment with methotrexate and adalimumab, an anti-tumor necrosis factor biological agent. The patient was successfully treated with doxycycline, while immunosuppressive treatment was discontinued.