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1Faculty of Medicine, Universidad de la Sabana, Chia, Colombia
2Health Sciences Faculty, Pontificia Universidad Javeriana, Cali, Colombia
3Internal Medicine Department, Universidad de la Sabana, Chia, Colombia
4Internal Medicine Department, Universidad del Bosque, Bogota, Colombia
JF Coronado-Sarmiento
, JP Coronado-López, E Tuta-Quintero, CM Mora, V Mayor
Introduction: Eosinophilic granulomatosis with polyangiitis (eGPA) is a necrotising vasculitis of small and medium calibre vessels, which affects mostly patients in their fourth to sixth decade of life, and it is a very uncommon aetiology for pulmonary fibrosis. Clinical case: A Hispanic 72-year-old female patient presents with a history of lower extremities pain, paraesthesia, oedema, and occasional macroscopic haematuria. During her hospitalisation, the patient presents, and images showed findings compatible with pulmonary fibrosis and alveolar haemorrhage, which require a biopsy, establishing the diagnosis of an eGPA. Discussion: eGPA is a low-incidence autoimmune vasculitis, with a high number of phenotypes which explain the broad clinical spectrum, but recent advances has helped to understand the physiopathology and its link with other conditions like pulmonary fibrosis. Conclusion: Early diagnosis and management of this condition is mandatory because it is the only factor that change the outcome of the patients.
Cite this article as: Coronado-Sarmiento JF, Coronado-López JP, Tuta-Quintero E, Mora CM, Mayor V. Late-Presenting Eosinophilic Granulomatosis with Polyangiitis as Cause of Pulmonary Fibrosis: A Case-Based Review. Mediterr J Rheumatol 2024;35(1):172-8.
Article Submitted: 16 Oct 2023; Revised Form: 19 Jul 2023; Article Accepted: 16 Oct 2023; Available Online: 12 Feb 2024
This work is licensed under a Creative Commons Attribution 4.0 International License.
©2024 The Author(s).
