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1Department of Rheumatology, SKIMS Soura Srinagar, India
2Department of Immunology and Molecular Medicine, SKIMS Soura Srinagar, India
3Deenanath Mangeshkar Hospital, Sassoon Gen Hospital Pune, India
4Kd Hospital, Ahmedabad Gujrat, India
5Synergy Rheumatology and Arthritis Clinic, India
6Fortis Hospital Gurgaon, India
7Moolchand Hospital Delhi, India
8Medanta-The Medicity Gurgaon, India
MA Bindroo
, S Bajad, N Mendiratta, NV Negalur, D Raval, G Ekbote, N Majid
Objectives: The aim of the study was to determine the clinical features & autoantibody profile of patients having late onset Systemic Lupus Erythematosus (SLE) and to compare with young onset SLE due to its scarce data from India. Methods: All patients who fulfilled the 1997 ACR criteria for SLE were included. Late onset patients were >50 years of age and young onset were 18 years at the time of first SLE-related symptom. Clinical, laboratory, and autoantibody (ENA 25 & APLA) profiles were compared between the two groups using descriptive statistics and chi square test. Results: Of the 305 patients, 69 had late onset (75.4% females). Mean age was 59.42±6.7 years (Late onset lupus) and 33.13±8.44 years (young onset lupus). The most common symptom was arthritis (60%) followed by oral ulceration (50%), fever (43%), and serositis (37.68%). Most common antibody was SSA/Ro60 (50%) and anti-SSA/Ro52 (46%). Interstitial lung disease (ILD) (14.5%), pancytopenia (13%) and diffuse alveolar haemorrhage (4.3%) were more frequent in late onset group. Statistically significant differences were found between two groups in terms of photosensitivity (p=0.009), malar rash (p=0.005), excessive hair loss (p=0.0006), Raynaud’s phenomenon (p=0.001), lymphadenopathy (p=0.01), nephritis (p=0.0007), ILD (p=0.01), anti-dsDNA (p=0.005), anti-nucleosome (p=0.01), anti-Sm (p=0.007), Ribosomes P0 (p=0.0004). Conclusion: This study suggests that late onset SLE has distinct clinical and serological manifestations when compared with young onset SLE patients.
Cite this article as: Bindroo MA, Majid N, Ekbote G, Raval D, Negalur NV, Mendiratta N, Bajad S, Gupta R. Late Onset Systemic Lupus Erythematosus - Clinical and Autoantibody Profile and its Comparison with Young Onset Systemic Lupus Erythematosus. Mediterr J Rheumatol 2023;34(4):454-59
Article Submitted: 14 Nov 2022; Revised Form: 14 Jan 2023; Article Accepted: 26 Jan 2023; Available Online: 29 Jul 2023
This work is licensed under a Creative Commons Attribution 4.0 International License.
©2023 The Author(s).
