Since its discovery, vitamin D was shown to have both immunostimulatory and immunomodulatory effects on the immune system. A growing body of evidence so far linked vitamin D deficiency with the development and severity of several systemic and organ specific autoimmune/inflammatory diseases, such as systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. In the present report, the multiple and diverse effects of vitamin D on the immune system are reviewed.

Cite this article as: Athanassiou L, Mavragani CP, Koutsilieris M. The Immunomodulatory Properties of Vitamin D. Mediterr J Rheumatol 2022;33(1):7-13.

Article Submitted: 1 Sep 2021; Revised Form: 26 Jan 2022; Article Accepted: 15 Feb 2022; Available Online: 31 Mar 2022

https://doi.org/10.31138/mjr.33.1.7

This work is licensed under a Creative Commons Attribution 4.0 International License.

©Athanassiou L, Mavragani CP, Koutsilieris M.