Immunology and Molecular Biology Laboratory, Nasonova Research Institute of Rheumatology, Moscow, Russia
Volume 28, Issue 3, September 2017
Sign in to download the Issue in PDF format.
1003134633
Mediterr J Rheumatol 2017; 28(3):116-26
Article Links
The clinical utility of gene expression examination in rheumatology
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease with unknown etiology that affects various pathways within the immune system, involves many other tissues and is associated with pain and joint destruction. Current treatments fail to address pathophysiological and biochemical mechanisms involved in joint degeneration and the induction of pain. Moreover, RA patients are extremely heterogeneous and require specific treatments, the choice of which is complicated by the fact that not all patients equally respond to therapy. Gene expression analysis offer tools for patient management and personalization of patient’s care to meet individual needs in controlling inflammation and pain and delaying joint destruction.
https://doi.org/10.31138/mjr.28.3.116
Keywords: rheumatoid arthritis, gene expression, TNFα, type I IFN-response genes, response to therapy, proteases, pain molecular markers
