Mediterr J Rheumatol 2021;32(2):118-23
Musculoskeletal Disorders in Chronic Obstructive Airway Diseases: A Neglected Clinical Entity
Authors Information

1. Department of Pulmonary Medicine, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, India
2. Department of Clinical Immunology and Rheumatology, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, India


Chronic obstructive pulmonary disease (COPD) is a lung disease that can affect various extra-pulmonary organs; one being the musculoskeletal system. Skeletal muscle dysfunction and osteoporosis are two important musculoskeletal disorders that have an impact on the quality of life in COPD patients in terms of morbidity and mortality. Treatment related adverse effects of COPD such as steroid-induced myopathy and osteoporosis are well recognised. Other comorbidities like sarcopenia, cardiovascular disease, metabolic diseases (diabetes mellitus, obesity, and thyroid diseases), chronic kidney disease, sleep apnoea, anaemia, and depression are also noted, which can contribute to impaired health status, increased healthcare utilisation, and even mortality. As well, it has been shown that autoimmunity and autoimmune rheumatic diseases (AIRDs) are linked to COPD. In this mini-review, we intend to give an overview of different types of musculoskeletal disorders associated with COPD.

Article Submitted: 14 Jul 2020; Revised Form: 9 Nov 2020; Article Accepted: 4 Apr 2021; Available Online: 30 Jun 2021


This work is licensed under a Creative Commons Attribution 4.0 International License (CC-BY). 

©Mohan Rao C, Singh P, Maikap D, Padhan P.