Volume 34, Issue 3, September 2023

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Mediterr J Rheumatol 2023;34(2):159-62
Chromosomal Distribution of Ankylosing Spondylitis Susceptibility Loci
Authors Information

Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran


Objectives: Previous studies have been indicated that susceptible loci of several multifactorial diseases were non-randomly distributed on human genome. There is no published data on chromosomal distribution of genes associated with risk of ankylosing spondylitis. Therefore, the present study was carried out. Methods: Published meta-analyses indexed in the PubMed database were used in the present study. Non-randomness chromosomal distribution of these loci was evaluated by the statistical method of Tai et al. Results: A total of 88 articles were obtained. There was 32 ankylosing spondylitis associated genes. The present study revealed that the human chromosome segments 6p11.2-p21.33, 19q13.2-q13.42, and 2q11.2-q14.1 were ankylosing spondylitis associated-rich regions by bearing 7, 6 and 4 susceptible loci, respectively. Conclusion: Ankylosing spondylitis associated-genes non-randomly have been distributed non-randomly on human chromosomes.

Cite this article as: Saadat M. Chromosomal Distribution of Ankylosing Spondylitis Susceptibility Loci. Mediterr J Rheumatol 2023;34(2):159-62,

Article Submitted: 08 Aug 2022; Revised Form: 30 Aug 2022; Article Accepted: 03 Sep 2022; Available Online: 30 Jun 2023


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©2023 The Author(s).