Loading...
 

Volume 35, Issue 1, March 2024



Sign in to download the Issue in PDF format.

Back to the list
Mediterr J Rheumatol 2022;33(4):444-8
Article Links
Successful Treatment of Systemic Lupus Erythematosus-Associated Thrombocytopenia with Eltrombopag: A Report of Two Cases and Literature Review
Firdevs Ulutaş, Zeynep Dündar Ök, Uğur Karasu, Veli Çobankara
Authors Information

Division of Rheumatology, Department of Internal Medicine, Pamukkale University Faculty of Medicine, Denizli, Turkey

F Ulutas, ZD Ök, U Karasu, V Çobankara

Keywords: systemic lupus erythematosus, thrombocytopenia, eltrombopag, intravenous immunoglobulin, anti-thrombopoietin receptor
References
  1. Velo-Garcia A, Castro SG, Isenberg DA. The diagnosis and management of the haematologic manifestations of lupus. J Autoimmun 2016;74:139-60.
  2. Miranda-Hernandez D, Cruz-Reyes C, Monsebaiz-Mora C, Gomez-Banuelos E, Angeles U, Jara LJ, et al. Active hematological manifestations of systemic lupus erythematosus lupus are associated with a high rate of in-hospital mortality. Lupus 2017;26(6):640-45.
  3. Cines DB, Liebman H, Stasi R. Pathobiology of secondary immune thrombocytopenia. Semin Hematol 2009;46(1 Suppl 2):S2-14.
  4. Lazarus AH, Semple JW, Cines DB. Innate and adaptive immunity in immune thrombocytopenia. Semin Hematol 2013;50 Suppl 1(1): S68-70.
  5. Kuwana M, Kaburaki J, Okazaki Y, Miyazaki H, Ikeda Y. Two types of autoantibody-mediated thrombocytopenia in patients with systemic lupus erythematosus. Rheumatology (Oxford) 2006;45(7):851-4.
  6. Harris EN, Asherson RA, Gharavi AE, Morgan SH, Derue G, Hughes GR. Thrombocytopenia in SLE and related autoimmune disorders: association with the anticardiolipin antibody. Br J Haematol 1985;59(2):227-30.
  7. Kado R, McCune WJ. Treatment of primary and secondary immune thrombocytopenia. Curr Opin Rheumatol 2019;31(3):213-22.
  8. Shima N, Sumida K, Kawada M, Sekine A, Yamanouchi M, Hiramatsu R, et al. Eltrombopag Improves Refractory Thrombocytopenia in a Patient with Systemic Lupus Erythematosus. Case Rep Rheumatol 2018(15);2018:6305356.
  9. Neunert C, Lim W, Crowther M, Cohen A, Solberg L Jr, Crowther MA. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. American Society of Hematology. Blood 2011(21); 117(16):4190-207.
  10. Nurden AT, Villard JF, Nurden P. New-generation drugs that stimulate platelet production in chronic immune thrombocytopenic purpura. Lancet 2009(2);373(9674):1562-9.
  11. Flynn JK, Dankers W, Morand EF. Could GILZ Be the Answer to Glucocorticoid Toxicity in Lupus? Front Immunol 2019(17);10:1684.
  12. Maroun MC, Ososki R, Andersen JC, Dhar JP. Eltrombopag as steroid-sparing therapy for immune thrombocytopenic purpura in systemic lupus erythematosus. Lupus 2015;24(7):746-50.
  13. Shobha V, Sanil S, Roongta R. Eltrombopag: Efficacy and Safety in Steroid Refractory Lupus-Associated Immune Thrombocytopenia. J Clin Rheumatol 2020;26(7):274-8.
  14. Lusa A, Carlson A. Safety and efficacy of thrombopoietin mimetics for refractory immune thrombocytopenic purpura in patients with systemic lupus erythematosus or antiphospholipid syndrome: a case series. Lupus 2018;27(10):1723-728.
  15. Boulon C, Vircoulon M, Constans J. Eltrombopag in systemic lupus erythematosus with antiphospholipid syndrome: thrombotic events. Lupus 2016;25(3):331.
  16. Guitton Z, Terriou L, Lega JC, Nove-Josserand R, Hie M, Amoura Z, et al. Risk of thrombosis with the anti-phospholipid syndrome in systemic lupus erythematosus treated with thrombopoietin-receptor agonists. Rheumatology (Oxford) 2018(1);57(8):1432-8.
  17. Chen Z, Zhong H, Dong G. Thrombocytopenia as a Prognostic Marker for Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis. Am J Med Sci 2019;357(6):461-7.
  18. Jung JH, Soh MS, Ahn YH, Um YJ, Jung JY, Suh CH, et al. Thrombocytopenia in Systemic Lupus Erythematosus: Clinical Manifestations, Treatment, and Prognosis in 230 Patients. Medicine (Baltimore) 2016;95(6):e2818.
  19. Leng Q, Wang W, Wang Y, Wu L. Treatment of severe thrombocytopenia associated with systemic lupus erythematosus in pregnancy with eltrombopag: A case report and literature review. J Clin Pharm Ther 2020 Dec 5. doi: 10.1111/jcpt.13321. Online ahead of print.
  20. Moreno Martinez MJ, Gallego P, Moreno Ramos MJ. Thrombopoietin-receptor agonist as a treatment of thrombocytopenia associated with systemic lupus erythematosus. Reumatol Clin 2016;12(1):57.
  21. Magnano L, Enriquez H, Esteve J, Cervera R, Espinosa G. Effectiveness of thrombopoietin-receptor agonists in the treatment of refractory immune thrombocytopenia associated to systemic lupus erythematosus. J Rheumatol 2014;41(9):1895-6.