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Volume 35, Issue 1, March 2024



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Mediterr J Rheumatol 2022;33(4):478-9
Article Links
Low Folate Levels are Associated with Strokes and Less Venous Thromboses in Primary Antiphospholipid Syndrome
Jozélio Freire Carvalho1, Yehuda Shoenfeld2,3,4
Authors Information
  1. Institute for Health Sciences from Federal University of Bahia, Salvador, BA, Brazil
  2. Zabludowicz Research Centre for Autoimmune Diseases, Sheba Medical Centre, Tel Hashomer, Israel
Keywords: antiphospholipid syndrome, thrombophilia, folic acid, vitamin, stroke
References
  1. de Carvalho JF, Levy RA, Shoenfeld Y. Antiphospholipid syndrome and antibodies. J Immunol Res 2014;2014:942869.
  2. Mazidi M, Katsiki N, Mikhailidis DP, Banach M; Lipid and Blood Pressure Meta-Analysis Collaboration (LBPMC) Group. Associations of serum uric acid with total and cause-specific mortality: Findings from individuals and pooling prospective studies. Atherosclerosis 2020 Mar;296:49-58.
  3. Qin X, Spence JD, Li J, Zhang Y, Li Y, Sun N, et al. Interaction of serum vitamin B12 and folate with MTHFR genotypes on risk of ischemic stroke. Neurology 2020 Mar 17;94(11):e1126-e1136.
  4. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006 Feb;4(2):295-306. 
  5. 5.Wisløff F, Jacobsen EM, Liestøl S. Laboratory diagnosis of the antiphospholipid syndrome. Thromb Res 2002;108:263-71.
  6. Ma Y, Peng D, Liu C, Huang C, Luo J. Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12 are significantly correlated with the categories of coronary artery diseases. BMC Cardiovasc Disord 2017 Jan 21;17(1):37.
  7. Huo Y, Qin X, Wang J, Sun N, Zeng Q, Xu X, et al. Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis. Int J Clin Pract 2012 Jun;66(6):544-51.
  8. Verhaar MC, Stroes E, Rabelink TJ. Folates and cardiovascular disease. Arterioscler Thromb Vasc Biol 2002;22:6-13.