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Volume 33, Issue 2, June 2022



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Mediterr J Rheumatol 2022;33(2):247-51
Intestinal Peripheral T-Cell Lymphoma in a Patient with Ankylosing Spondylitis Under Treatment with Infliximab: A Case Report and Review of the Literature
Authors Information

1Division of Rheumatology, Department of Internal Medicine, Pamukkale University Faculty of Medicine, Denizli, Turkey

2Department of Internal Medicine, Pamukkale University Faculty of Medicine, Denizli, Turkey

3Division of Gastroenterology, Department of Internal Medicine, Pamukkale University Faculty of Medicine, Denizli, Turkey

4Department of Pathology, Pamukkale University Faculty of Medicine, Denizli, Turkey

F Ulutaş, C Korkmaz, H Yılmaz, D Akça, E Çomut, M Çelık, V Çobankara

Abstract

Background: Recent literature involves many cases with lymphoma and ankylosing spondylitis (AS) with or without the use of TNF inhibitors. Herein, we report a patient, a 56-year-old Human Leukocyte Antigen-B27 (HLA-B27) positive man with four years history of AS who was still under treatment with infliximab with clinical remission. He was admitted with a new-onset, 6-week history of bloody diarrhoea with mucus, abdominal pain, fever, and weight loss. An ileocolonoscopy showed linear ileocecal valve ulcers. Histopathological findings of ileocecal valve ulcers revealed peripheral T-cell lymphoma of the small intestine. Infliximab was interrupted because of the possible progression of the lymphoma. Methods: We aimed to emphasize the underlying potential pathogenic mechanisms and to review the related literature. A literature search was conducted in the PubMed database between January 1980 and November 2020. The keywords including 'ankylosing spondylitis' and 'lymphoma' were used. Conclusion: TNFi use, immunosuppression, and chronic inflammation may be related to the development of lymphoma in chronic inflammatory diseases. Ileocecal valve involvement should not be interpreted as inflammatory bowel disease, infection, or vasculitis in the presence of red flags.

Cite this article as: Ulutaş F, Korkmaz C, Yılmaz H, Akça D, Çomut E, Çelık M, Çobankara V. Intestinal Peripheral T-Cell Lymphoma in a Patient with Ankylosing Spondylitis Under Treatment with Infliximab: ACase Report and Review of the Literature. Mediterr J Rheumatol 2022;33(2):247-51.

Article Submitted: 23 Feb 2021; Revised Form: 25 May 2021; Article Accepted: 15 Jun 2021; Available Online: 30 Jun 2022

https://doi.org/10.31138/mjr.33.2.247
This work is licensed under a Creative Commons Attribution 4.0 International License.

©Ulutaş F, Korkmaz C, Yılmaz H, Akça D, Çomut E, Çelık M, Çobankara V.