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Volume 33, Issue 1, March 2022



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Mediterr J Rheumatol 2022;33(1):106-8
Vitamin D Deficiency in Primary Sjögren’s Syndrome: Association with Clinical Manifestations and Immune Activation Markers
Authors Information

1Department of Rheumatology, St. Paul’s Hospital, Thessaloniki, Greece

2Molecular Physiology-Clinical Application Unit, Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece

3Department of Rheumatology, Asclepeion Hospital, Voula, Athens, Greece

4Department of Endocrinology, Asclepeion Hospital, Voula, Athens, Greece

5Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece

Abstract

Vitamin D is an agent involved in bone and mineral homeostasis. It has been recognized as a potent immunomodulator. It has immune-enhancing properties, and it induces immune tolerance. Vitamin D deficiency has been shown to be related to the development of autoimmune disorders. Vitamin D deficiency has been observed in patients with rheumatoid arthritis (RA) and it has been shown to be related with disease activity. Vitamin D deficiency has also been found in patients with systemic lupus erythematosus (SLE) and it was shown to be related to disease activity and renal involvement. Vitamin D deficiency has also been observed in multiple sclerosis. Vitamin D has been found to act as a supplemental therapeutic agent in multiple sclerosis. Sjögren’s syndrome is a systemic autoimmune disease affecting the exocrine glands, known as an autoimmune epithelitis. The disease has a complex pathogenesis, requiring a genetic background, immune cell activation, and autoantibody production. The disease affects the exocrine glands, lacrimal, and salivary glands leading to ocular and oral dryness. Vitamin D levels have been measured in patients with Sjögren’s syndrome and an association was observed between low vitamin D levels, peripheral neuropathy and the presence of lymphoma. In other cohorts, such as a Turkish cohort, vitamin D deficiency was observed in patients with Sjögren’s syndrome. The aim is to measure serum vitamin D levels in consecutive patients with primary Sjögren’s syndrome and investigate the relationship between vitamin D levels and the presence of immunologic markers, clinical, serological, and histopathological characteristics.



Cite this article as: Athanassiou P, Mavragani C, Athanassiou L, Kostoglou-Athanassiou I, Koutsilieris M. Vitamin D Deficiency in Primary Sjögren’s Syndrome: Association with Clinical Manifestations and Immune Activation Markers. Mediterr J Rheumatol 2022;33(1):106-8.

Article Submitted: 21 Mar 2022; Article Accepted: 28 Mar 2022; Available Online: 31 Mar 2022

https://doi.org/10.31138/mjr.33.1.106

This work is licensed under a Creative Commons Attribution 4.0 International License.

©Athanassiou P, Mavragani C, Athanassiou L, Kostoglou-Athanassiou I, Koutsilieris M.