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Volume 33, Issue 1, March 2022



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Mediterr J Rheumatol 2021;32(4):358-62
Quiescent Systemic Lupus Erythematosus Manifesting with Thrombotic Thrombocytopenic Purpura and Acute Renal Failure: A Case Report and Short Literature Review
Authors Information
Department of Rheumatology, Agios Andreas General Hospital, Patras, Greece
Abstract
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, and haematologic manifestations are part of its spectrum. Herein, we report a case of a patient with a long-standing diagnosis of SLE, presenting with thrombotic thrombocytopenic purpura (TTP) and acute renal failure, without co-existent clinical and laboratory markers of disease activity, causing diagnostic questions. A short literature review concerning TTP and SLE is also presented. TTP is a rare syndrome of thrombotic microangiopathy, which represents a medical urgency and carries significant morbidity and mortality if left untreated. SLE has been correlated with the occurrence of TTP, often with atypical presentation and worse prognosis. 

Article Submitted: 19 Nov 2020; Revised Form: 14 Feb 2021; Article Accepted: 20 Feb 2021; Available Online: 27 Dec 2021

https://doi.org/10.31138/mjr.32.4.358

This work is licensed under a Creative Commons Attribution 4.0 International License. 

©Melissaropoulos K, Georgiou P.