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Volume 32, Issue 3, September 2021




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Mediterr J Rheumatol 2021;32(3):243-8
Cut-Off Value of Serum Uric Acid for Development of Gout Disease in Patients with Multiple Co-Morbidities
Authors Information

1. Division of Rheumatology, Department of Internal Medicine, Pamukkale University Faculty of Medicine, Denizli, Turkey

2. Department of Internal Medicine, Pamukkale University Faculty of Medicine, Denizli, Turkey

3. Department of Public Health, Pamukkale University Faculty of Medicine, Denizli, Turkey

F Ulutas, NY Çelikyürek, V Çobankara, A Bozdemir, CA Yaşar 

Abstract

Objective: This study aimed to determine the association between hyperuricemia, comorbid diseases and risk of developing gout disease in a Turkish population in a long follow-up period. Methods: A total of 2000 Turkish adults were cross-sectionally analysed for serum urate levels in 2009 at the Pamukkale University Faculty of Medicine. All patients on regular follow-up at our tertiary health center (n=1322) were included in this study. Demographic features (age and gender), comorbid clinical conditions, and medication use were noted. The risk of developing gout and the determinant factors were investigated. Multivariate logistic regression analysis was performed to analyse causative effects of factors while receiver operating characteristic (ROC) curve analysis was used to identify optimal cut-off values of uric acid level for predicting the development of gout. Results: Among 1322 patients, the mean age was 56.9 (SD:14.68) years. 57.3% (n=758) of the patients were female. The most common co-morbid disease was chronic kidney disease (581, 43%), followed by hypertension (522, 39.4%). Gout developed in 25 patients (1.8%). Gout development risk and presence of all the above comorbidities were significantly higher in patients with serum urate ≥7mg/dl compared with <7mg/dl. Male gender and not using urate lowering drugs were the main risk factors for developing gout disease. ROC analysis of serum uric acid levels identified a cut-off value of >7 (AUC: 0.776, sensitivity 86.96%, specificity 66.74%). Conclusion: There is still a dilemma concerning the culprit effects of both comorbidities and hyperuricemia on the risk of developing gout disease.


Cite this article as: Ulutaş F, Bozdemir A, Çelikyürek NA, Yaşar CA, Çobankara V.  Cut-Off Value of Serum Uric Acid for Development of Gout Disease in Patients with Multiple Co-Morbidities. Mediterr J Rheumatol 2021;32(3):243-8.

Article Submitted: 12 Dec 2020; Revised Form: 13 Jan 2021; Article Accepted: 20 Jun 2021; Available Online: 30 Sep 2021

 

https://doi.org/10.31138/mjr.32.3.243

This work is licensed under a Creative Commons Attribution 4.0 International License.

©Ulutaş F, Bozdemir A, Çelikyürek NA, Yaşar CA, Çobankara V.