1. Department of Radiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
2. Department of Internal Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
3. School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
962843634
Mediterr J Rheumatol 2019;30(4):216-9
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Association between serum Vitamin D deficiency and Knee Osteoarthritis
Abstract
Objective: Levels of Vitamin D may influence the development of knee osteoarthritis (OA), which is one of the most common joint diseases. The aim of this study was to investigate the association between serum Vitamin D deficiency and knee OA in Ardabil and Iran. Methods: One hundred fifty-eight consecutive patients referred to rheumatology clinic of Ardabil City Hospital were recruited in the study. All the participants underwent x-rays in two anterior-posterior and side views of the knees. Staging of knee OA was done according to Kellgren-Lawrence criteria. Seventy-nine individuals with clinical and radiographic signs of knee OA were defined as the case group, and those without clinical and radiographic signs of the disease were defined as a control group. Haematology and biochemical profile including measurement of 25-hydroxyvitamin D serum level was performed in the participants. Results: The mean age of patients and controls were 54.12 ± 4.67 and 55.37 ± 5.12 years, respectively. The average serum vitamin D in OA patients and controls were 26.8±6.2 ng / ml and 28.1±5.3ng/ml, respectively (p=0.36). There was a significant association between serum vitamin D and staging of knee OA (p=0.001). Based on vitamin D levels, most of patients with vitamin D deficiency were in stages III and IV. Conclusion: The findings of the study suggest that vitamin D deficiency should be considered in patients with OA and treated accordingly.©Anari H, Enteshari-Moghaddam A, Abdolzadeh Y.
https://doi.org/10.31138/mjr.30.4.216