Loading...
 
Mediterr J Rheumatol 2017;28(3):127-32
The effect of vitamin D on disease activity, fatigue and interferon signature gene expression in systemic lupus erythematosus
Authors Information

Rheumatology Department, Mater Dei Hospital, Msida, Malta

References
  1. Tsokos G C. Systemic lupus erythematosus. N Engl J Med 2011;365:2110-2121.
  2. Kim J M, Park S H, Kim H Y, Kwok S K. A Plasmacytoid Dendritic Cells-Type I Interferon Axis Is Critically Implicated in the Pathogenesis of Systemic Lupus Erythematosus. Int J Mol Sci 2015;16:14158-70.
  3. Huang X, Dorta-Estremera S, Yao Y, Shen N, Cao W. Predominant role of plasmacytoid dendritic cells in stimulating systemic autoimmunity. Front Immunol 2015;6:526.
  4. Rönnblom L, Alm G V. Systemic lupus erythematosus and the type I interferon system. Arthritis Res Ther 2003;5:68-75.
  5. Wintermeyer E, Ihle C, Ehnert S, Stöckle U, Ochs G, de Zwart P, et al. Crucial Role of Vitamin D in the Musculoskeletal System. Nutrients 2016;8:319.
  6. Iruretagoyena M, Hirigoyen D, Naves R, Burgos P I. Immune Response Modulation by Vitamin D: Role in Systemic Lupus Erythematosus. Front Immunol 2015;6:513.
  7. Spiro A, Buttriss J L. Vitamin D: An overview of vitamin D status and intake in Europe. Nutr Bull 2014;39:322-50.
  8. Kamen D L, Aranow C. The link between vitamin D deficiency and systemic lupus erythematosus. Curr Rheumatol Rep 2008;10:273-80.
  9. Sakthiswary R, Ali Raymond A. The Clinical Significance of Vitamin D in Systemic Lupus Erythematosus: A Systematic Review. PLOS One 2013;8:e55275.
  10. Rai G, Rai R, Saeidian A H, Rai M. Microarray to deep sequencing: transcriptome and miRNAprofiling to elucidate molecular pathways in systemic lupus erythematosus. Immunol Res 2016;64:14-24.
  11. Arasappan D, Tong W, Mummaneni P, Fang H, Amur S. Meta-analysis of microarray data using a pathway-based approach identifies a 37-gene expression signature for systemic lupus erythematosus in human peripheral blood mononuclear cells. BMC Med 2011;9:65.
  12. Ritterhouse L L, Crowe S R, Niewold T B, Kamen D L, Macwana S R, Roberts V C, et al. Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus. Ann Rheum Dis 2011;70:1569-74.
  13. Mandal M, Tripathy R, Panda A K, Pattanaik S S, Dakua S, Pradhan A K, et al. Vitamin D levels in Indian systemic lupus erythematosus patients: association with disease activity index and interferon alpha. Arthritis Res Ther 2014;16:1-8. 
  14. Aranow C, Kamen D L, Dall'Era M, Massarotti E M, Mackay M C, Koumpouras F, et al. Randomized, Double-Blind, Placebo-Controlled Trial of the Effect of Vitamin D3 on the Interferon Signature in Patients With Systemic Lupus Erythematosus. Arthritis Rheumatol 2015;67:1848-57.
  15. Becker A, Fischer R, Schneider M. Bone density and 25-OH vitamin D serum level in patients with systemic lupus erythematosus. Z Rheumatol 2001;60:352-8.
  16. Wu P W, Rhew E Y, Dyer A R, Dunlop D D, Langman C B, Price H, et al. 25-hydroxyvitamin D and cardiovascular risk factors in women with systemic lupus erythematosus. Arthritis Rheum 2009;61:1387-95.
  17. Borba V Z, Vieira J G, Kasamatsu T, Radominski S C, Sato E I, Lazaretti-Castro M. Vitamin D deficiency in patients with active systemic lupus erythematosus.  Osteoporosis Int 2009;20:427-33.  
  18. Wright T B, Shults J, Leonard M B, Zemel B S, Burnham J M. Hypovitaminosis D is associated with greater body mass index and disease activity in pediatric systemic lupus erythematosus. J Pediatr 2009;155:260-5.
  19. Amital H, Szekanecz Z, Szucs G, Danko K, Nagy E, Csépány T, et al. Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D? Ann Rheum Dis 2010;69:1155-7.     
  20. Ben-Zvi I, Aranow C, Mackay M, Stanevsky A, Kamen D L, Marinescu L M, et al. The impact of vitamin D on dendritic cell function in patients with systemic lupus erythematosus. PLoS One 2010;5,e9193.
  21. Hamza R T, Awwad K S, Ali M K, Hamed A. Reduced serum concentrations of 25-hydroxy vitamin D in Egyptian patients with systemic lupus erythematosus: relation to disease activity. Med Sci Monit 2011;17:CR711–8.
  22. Bonakdar ZS, Jahanshahifar L, Jahanshahifar F, Gholamrezaei A. Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus. Lupus 2011;20:1155-60.
  23. Szodoray P, Tarr T, Bazso A, Poor G, Szegedi G, Kiss E. The immunopathological role of vitamin D in patients with SLE: data from a single centre registry in Hungary. Scand J Rheumatol 2011;40:122-6.  
  24.  
  25. Ezzat Y, Sayed S, Gaber W, Mohey A M, Kassem T W. 25-Hydroxyvitamin D levels and its relation to disease activity and cardiovascular risk factors in women with systemic lupus erythematosis. Egyptian Rheumatol 2011;33:195-201.                
  26. Mok CC, Birmingham D J, Leung H W, Hebert L A, Song H, Rovin B H. Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis. Rheumatology 2012;51:644-52.
  27. Yeap S S, Othman A Z, Zain A A, Chan S P. Vitamin D levels: its relationship to bone mineral density response and disease activity in premenopausal Malaysian systemic lupus erythematosus patients on corticosteroids. Int J Rheum Dis 2012;15:17-24.
  28. Reynolds J A, Haque S, Berry J L, Pemberton P, Teh L S, Ho P, et al. 25-Hydroxyvitamin D deficiency is associated with increased aortic stiffness in patients with systemic lupus erythematosus. Rheumatology 2012;51:544-51.
  29. Sumethkul K, Boonyaratavej S, Kitumnuaypong T, Angthararuk S, Cheewasat P, Manadee N, et al. The predictive factors of low serum 25-hydroxyvitamin D and vitamin D deficiency in patients with systemic lupus erythematosus. Rheumatol Int 2012;33:1461-7.
  30. Casella C B, Seguro L P, Takayama L, Medeiros D, Bonfa E, Pereira R M. Juvenile onset systemic lupus erythematosus: a possible role for vitamin D in disease status and bone health. Lupus. 2012;21:1335-42.
  31. Abou-Raya A, Abou-Raya S, Helmii M. The effect of vitamin D supplementation on inflammatory and hemostatic markers and disease activity in patients with systemic lupus erythematosus: a randomized placebo controlled trial. J Rheumatol 2013;40: 265-72.
  32. Petri M, Bello K J, Fang H, Magder L S. Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio. Arthritis Rheum 2013;65:1865-71.
  33. Lertratanakul A, Wu P, Dyer A, Urowitz M, Gladman D, Fortin P, et al. 25-Hydroxyvitamin D and cardiovascular disease in patients with systemic lupus erythematosus: data from a large international inception cohort. Arthritis Care Res 2014;66:1167-76. 
  34. Lima G L, Paupitz J, Aikawa N E, Takayama L, Bonfa E, Pereira R M. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial. Arthritis Care Res 2016;68:91-8.
  35. Chen S, Sims G P, Chen X X, Gu Y Y, Chen S, Lipsky P E. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 2007;179:1634-47.
  36. Orbach H, Zandman-Goddard G, Amital H, Barak V, Szekanecz Z, Szucs G, et al. Novel biomarkers in autoimmune diseases: prolactin, ferritin, vitamin D, and TPA levels in autoimmune diseases. Ann N Y Acad Sci 2007;1109:385-400.
  37. Ruiz-Irastorza G, Egurbide M V, Olivares N, Martinez-Berriotxoa A, Aguirre C. Vitamin D deficiency in systemic lupus erythematosus: prevalence, predictors and clinical consequences. Rheumatology 2008;47:920-23.
  38. Ruiz-Irastorza G, Gordo S, Olivares N, Egurbide M V, Aguirre C. Changes in vitamin D levels in patients with systemic lupus erythematosus: Effects on fatigue, disease activity, and damage. Arthritis Care Res 2010;62:1160-5.
  39. Toloza S, Cole D, Gladman D, Ibanez D, Urowitz M. Vitamin D insufficiency in a large female SLE cohort. Lupus 2010;19,13-9.
  40. Kim H A, Sung J M, Jeon J Y, Yoon J M, Suh C H. Vitamin D may not be a good marker of disease activity in Korean patients with systemic lupus erythematosus. Rheumatol Int 2011;31:1189-94.
  41. Souto M, Coelho A, Guo C, Mendonça L, Argolo S, Papi J, et al. Vitamin D insufficiency in Brazilian patients with SLE: prevalence, associated factors, and relationship with activity. Lupus 2011;20:1019-26.
  42. López-Robles C, Rios-Fernández R, Callejas-Rubio J L, Ortego-Centeno N. Vitamin D deficiency in a cohort of patients with systemic lupus erythematous from the South of Spain. Lupus. 2011;20:330-1.
  43. Munoz-Ortego J, Torrente-Segarra V, Prieto-Alhambra D, Salman-Monte T, Carbonell-Abello J. Prevalence and predictors of vitamin D deficiency in non-supplemented women with systemic lupus erythematosus in the Mediterranean region: a cohort study. Scand J Rheumatol 2012;41:472-5.
  44. Fragoso T S, Dantas A T, Marques C D, Rocha Junior LF, Melo JH, Costa AJ et al. 25-Hydroxyivitamin D3 levels in patients with systemic lupus erythematosus and its association with clinical parameters and laboratory tests. Rev Bras Reumatol 2012;52:60-5.
  45. Terrier B, Derian N, Schoindre Y, Chaara W, Geri G, Zahr N, et al. Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation. Arthritis Res Ther 2012;14:R221.
  46. Bogaczewicz J, Sysa-Jedrzejowska A, Arkuszewska C, Zabek J, Kontny E, McCauliffe D, et al. Vitamin D status in systemic lupus erythematosus patients and its association with selected clinical and laboratory parameters. Lupus 2012;21:477-84.
  47. Monticielo O A, Brenol J C, Chies J A, Longo M G, Rucatti G G, Scalco R, et al. The role of BsmI and FokI vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D in Brazilian patients with systemic lupus erythematosus. Lupus. 2012;21:43-52.
  48. Robinson A B, Thierry-Palmer M, Gibson KL, Rabinovich CE. Disease activity, proteinuria, and vitamin D status in children with systemic lupus erythematosus and juvenile dermatomyositis. J Pediatr 2012;160:297-302.
  49. Chaiamnuay S, Chailurkit LO, Narongroeknawin P, Asavatanabodee P, Laohajaroensombat S, Chaiamnuay P. Current daily glucocorticoid use and serum creatinine levels are associated with lower 25(OH) vitamin D levels in Thai patients with systemic lupus erythematosus. J Clin Rheumatol 2013;19:121-5.
  50. Attar S M, Siddiqui A M. Vitamin d deficiency in patients with systemic lupus erythematosus. Oman Med J 2013;28:42-7.
  51. Sahebari M, Nabavi N, Salehi M. Correlation between serum 25(OH)D values and lupus disease activity: an original article and a systematic review with meta-analysis focusing on serum VitD confounders. Lupus 2014;23:1164-77.
  52. Andreoli L, Dall'Ara F, Piantoni S, Zanola A, Piva N, Cutolo M, et al. A 24-month prospective study on the efficacy and safety of two different monthly regimens of vitamin D supplementation in pre-menopausal women with systemic lupus erythematosus. Lupus 2015;24:499-506.
  53. Ravenell R L, Kamen D L, Spence J D, Hollis B W, Fleury T J, Janech M G, et al. Premature Atherosclerosis Is Associated With Hypovitaminosis D and Angiotensin-Converting Enzyme Inhibitor Non-use in Lupus Patients. Am J Med Sci 2012;344:268-3.
  54. Zonana-Nacach A, Roseman J M, McGwin G, Friedman A W, Baethge B A, Reveille J D, et al. Systemic lupus erythematosus in three ethnic groups. VI.Factors associated with fatigue within 5 years of criteria diagnosis. Lupus 2000;9:101-9.
  55. Krupp L B, LaRocca N G, Muir-Nash J, Steinberg A D. The fatigue severity scale: application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 1989;46:1121-3.
  56. Tench C M, McCurdie I, White P D, D’Cruz D P. The prevalence and associations of fatigue in systemic lupus erythematosus. Rheumatology 2000;39:1249-54.
  57. Wang B, Gladman D D, Urowitz M B. Fatigue in lupus is not correlated with disease activity. J Rheumatol 1998;25:892-5.
  58. Omdal R, Waterloo K, Koldingsnes W, Husby G, Mellgren S .Fatigue in patients with systemic lupus erythematosus: the psychosocial aspects. J Rheumatol 2003;30:283-7.
  59. Jump R, Robinson M E, Armstrong A, Barnes E V, Kilbourn K M, Richards H B. Fatigue in systemic lupus erythematosus: contributions of disease activity, pain, depression, and perceived social support. J Rheumatol 2005;32:1699-705.
  60. Daltroy L H, Robb-Nicholson C, Iversen M D, Wright E A, Liang M H. Effectiveness of minimally supervised home aerobic training in patients with systemic rheumatic disease. Br J Rheumatol 1995;34:1064-9.
  61. Tench C M, McCarthy J, McCurdie I, White P D, D’Cruz D P. Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise. Rheumatology 2003;42: 1050-4.
  62. Tayer W G, Nicassio P M, Weisman M H, Schuman C, Daly J. Disease status predicts fatigue in systemic lupus erythematosus. J Rheumatol 2001;28:1999-2007.
  63. Wysenbeek A J, Leibovici L, Weinberger A, Guedj D. Fatigue in systemic lupus erythematosus: prevalence and relation to disease expression. Br J Rheumatol 1993;32:633-5.
  64. Bruce I N, Mak V C, Hallet D C, Gladman D, Urowitz M. Factors associated with fatigue in patients with systemic lupus erythematosus. Ann Rheum Dis 1999;58:379-81.
  65. Ad Hoc Committee on Systemic Lupus Erythematosus Response Criteria for Fatigue. Measurement of fatigue in systemic lupus erythematosus: a systematic review. Arthritis Rheum 2007;57:1348-57.
  66. Stockton K A, Kandiah D A, Paratz J D, Bennell K L. Fatigue, muscle strength and vitamin D status in women with systemic lupus erythematosus compared with healthy controls. Lupus 2012;21:271-8.