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Mediterr J Rheumatol 2016;27(1):15-9
Co-stimulation modulation improves Rheumatoid Arthritis despite reducing the proportion of CD4+CD25high T regulatory cells
Authors Information
1: Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece

2: Hematology Laboratory, Unit of Molecular Biology, University Hospital of Ioannina, Ioannina, Greece
References
  1. van Amelsfort J M, Jacobs K M, Bijlsma J W, Lafeber F P, Taams L S. CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum 2004;50:2775-85.
  2. Lawson C A, Brown A K, Bejarano V, Douglas S H, Burgoyne C H, Greenstein A S, et al. Early rheumatoid arthritis is associated with a deficit in the CD4+CD25high regulatory T cell population in peripheral blood. Rheumatology (Oxford) 2006;45:1210-7.
  3. Cao D, Malmström V, Baecher-Allan C, Hafler D, Klareskog L, Trollmo C. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol 2003;33:215-23.
  4. Walter G J, Fleskens V, Frederiksen K S, Rajasekhar M, Menon B, Gerwien J G, et al. Phenotypic, functional and gene expression profiling of peripheral CD45RA + and CD45RO + CD4+CD25+CD127low regulatory T cells in rheumatoid arthritis. Arthritis Rheumatol 2016;68:103-6.
  5. Ehrenstein M R, Evans J G, Singh A, Moore S, Warnes G, Isenberg D A, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF alpha therapy. J Exp Med 2004;200:277-85.
  6. Haribhai D, Williams J B, Jia S, Nickerson D, Schmitt E G, Edwards B, Ziegelbauer J, et al. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity 2011;35:109-22.
  7. Afzali B, Lombardi G, Lechler R I, Lord G M. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol 2007;148:32-46.
  8. Kikuchi J, Hashizume M, Kaneko Y, Yoshimoto K, Nishina N, Takeuchi T. Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response. Arthritis Res Ther 2015;17:10.
  9. Lohr J, Knoechel B, Kahn E C, Abbas A K. Role of B7 in T cell tolerance. J Immunol. 2004; 173: 5028-35.
  10. Liang S, Alard P, Zhao Y, Parnell S, Clark S L, Kosiewicz M M. Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus. J Exp Med 2005;201:127-37.
  11. Williams K M, Dotson A L, Otto A R, Kohlmeier J E, Benedict S H. Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation. Cell Immunol 2011; 271: 418-27.
  12. Cools N, Ponsaerts P, Van Tendeloo V F, Berneman Z N. Regulatory T cells and human disease. Clin Dev Immunol 2007;2007:89195.
  13. Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, et al. CTLA -4 control over Foxp3+ regulatory T cell function. Science 2008;322:271-5.
  14. Friedline R H, Brown D S, Nguyen H, Kornfeld H, Lee J, Zhang Y, et al. CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med 2009;206:421-34.
  15. Liu W, Putnam A L, Xu-Yu Z, Szot G L, Lee M R, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006;203:1701-11.
  16. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006;203:1693-700.
  17. Álvarez-Quiroga C, Abud-Mendoza C, Doníz-Padilla L, Juárez-Reyes A, Monsiváis-Urenda A, et al. CTLA -4-Ig therapy diminishes the frequency but enhances the function of Treg cells in patients with rheumatoid arthritis. J Clin Immunol 2011;31:588-95.
  18. Adler S, Körner M, Förger F, Huscher D, Caversaccio M D, Villiger P M. Evaluation of histological, serological and clinical changes in response to abatacept treatment of primary Sjögren’s syndrome: A pilot study. Arthritis Care Res (Hoboken) 2013;65:1862-8.
  19. Picchianti Diamanti A, Rosado M M, Scarsella M, Germano V, Giorda E, Cascioli S, et al. Abatacept (cytotoxic T lymphocyte antigen 4-immunoglobulin) improves B cell function and regulatory T cell inhibitory capacity in rheumatoid arthritis patients non-responding to anti-tumour necrosis factor-α agents. Clin Exp Immunol 2014;177:630-40.
  20. Bonelli M, Göschl L, Blüml S, Karonitsch T, Hirahara K, Ferner E, et al. Abatacept (CTLA -4Ig) treatment reduces T cell apoptosis and regulatory T cell suppression in patients with rheumatoid arthritis. Rheumatology (Oxford) 2015 Dec 16. [Epub ahead of print]
  21. Wang J, Ioan-Facsinay A, van der Voort E I, Huizinga T W, Toes RE. Transient expression of FO XP3 in human activated nonregulatory CD4+ T cells. Eur J Immunol 2007;37:129-38.
  22. Kmieciak M, Gowda M, Graham L, Godder K, Bear H D, Marincola FM, et al. Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. J Transl Med 2009;7:89.
  23. Yang H X, Zhang W, Zhao L D, Li Y, Zhang F C, Tang F L, et al. Are CD4+CD25-Foxp3+ cells in untreated new-onset lupus patients regulatory T cells? Arthritis Res Ther 2009;11:R153.
  24. Wilde B, Thewissen M, Damoiseaux J, Knippenberg S, Hilhorst M, van Paassen P, et al. Regulatory B cells in ANCA -associated vasculitis. Ann Rheum Dis 2013;72:1416-9.
  25. Byng-Maddick R, Ehrenstein M R. The impact of biological therapy on regulatory T cells in rheumatoid arthritis. Rheumatology (Oxford) 2015;54:768-75.